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Fexofenadine hydrochloride b
CAS No. 153439-40-8
Fexofenadine hydrochloride b( Terfenidine carboxylate hydrochloride | MDL-16455 hydrochloride | Fexofenadine HCl | MDL 16455A | Telfast | Allegra )
Catalog No. M19417 CAS No. 153439-40-8
Fexofenadine is a second generation antihistamine that is used for the treatment of allergic rhinitis angioedema and chronic urticaria.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 41 | In Stock |
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| 25MG | 64 | In Stock |
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| 50MG | 87 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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Biological Information
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Product NameFexofenadine hydrochloride b
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NoteResearch use only, not for human use.
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Brief DescriptionFexofenadine is a second generation antihistamine that is used for the treatment of allergic rhinitis angioedema and chronic urticaria.
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DescriptionFexofenadine is a second generation antihistamine that is used for the treatment of allergic rhinitis angioedema and chronic urticaria.
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In VitroFexofenadine (1-100 μM; 1 h) inhibits the expression of IL-6 protein in nasal fibroblasts in a dose-dependent manner.Fexofenadine (1-100 μM; 1 h) blocks phosphorylated p38 activation in histamine-induced nasal fibroblasts, but shows no effect on either pERK or pJNK.Western Blot Analysis Cell Line:Nasal Fibroblasts Concentration:100 μM Incubation Time:1 hourResult:Blocked pp38 activation in histamine-induced nasal fibroblasts, showed histamine-induced IL-6 production mediated by the p38 pathway.
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In VivoFexofenadine hydrochloride (oral administration; 5-20 mg/kg; once daily; 3 w) suppresses both eosinophilia and systemic anaphylaxis in C57BL/6 mice infected with T. spiralis. Animal Model:C57BL/6 mice infected with Trichinella spiralis Dosage:5, 10 and 20 mg/kg Administration:Oral administration; 5, 10 and 20 mg/kg; once daily; 3 weeks Result:Inhibited eosinophilia in a dose-dependent manner.Suppressed the decrease in rectal temperature (p<0.01), a marker for systemic anaphylaxis.
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SynonymsTerfenidine carboxylate hydrochloride | MDL-16455 hydrochloride | Fexofenadine HCl | MDL 16455A | Telfast | Allegra
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PathwayGPCR/G Protein
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TargetHistamine Receptor
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RecptorHistamine H1 receptor
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Research AreaMetabolic Disease
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IndicationAllergic rhinitis; Urticaria
Chemical Information
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CAS Number153439-40-8
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Formula Weight538.13
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Molecular FormulaC32H39NO4·HCl
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Purity>98% (HPLC)
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SolubilityDMSO:26.9 mg/mL (50 mM)
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SMILESCl.CC(C)(C(O)=O)c1ccc(cc1)C(O)CCCN1CCC(CC1)C(O)(c1ccccc1)c1ccccc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Bachert C et al. A review of the efficacy of desloratadine fexofenadine and levocetirizine in the treatment of nasal congestion in patients with allergic rhinitis. Clin Ther 31 (5): 921-44.
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